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This amino acid has been around for donkey’s years and its efficacy studied immensely during. The Acetyl component of this improves the ability to cross the blood brain barrier, improve dopamine and by improving dopamine – it improves other areas such as cognition, learning, attention, memory, desire, pleasure, punishment, reward, motivation, sleep, mood, behaviour, and voluntary movement. It also upregulates the oxidation of fatty acids for the purpose of burning fat and this is done via the Mitochondrial carnitine palmitoyltransferase 1 (CPT1) Pathway. Consuming Acetyl L-Carnitine upregulates the rate limiting fat burning step meaning that you can burn more fat when you exercise.
Dietary supplementation of Acetyl L-Carnitine exerts neuroprotective, neurotrophic, anti-depressive and analgesic effects in painful conditions. Acetyl L-Carnitine also has antioxidant and anti-apoptotic activity. Moreover, Acetyl L-Carnitine exhibits positive effects on mitochondrial metabolism, and shows promise in the treatment of aging and neurodegenerative pathologies by slowing the progression of mental deterioration.1
Fat exhibits a relatively low maximal rate of oxidation in vivo, which begins to decline at around 65% of VO2max when muscle glycogen becomes the major fuel. It is thought that if the rate of fat oxidation during endurance exercise could be augmented, then muscle glycogen depletion could be delayed and endurance improved.
Mitochondrial carnitine palmitoyltransferase 1 (CPT1) is thought to be the rate-limiting step in skeletal muscle fat oxidation, but there are several other potential control points that could influence the decline in the rate of fat oxidation during intense endurance exercise including: (1) regulation of lipolysis within adipose tissue; (2) delivery of free fatty acids from adipose tissue to skeletal muscle; (3) transport of fatty acids across the muscle cell membrane and within the cell cytosol; and (4) intramitochondrial enzymatic reactions distal to CPT1.2 Consuming Acetyl L-Carnitine upregulates the rate limiting fat burning step meaning that you can burn more fat when you exercise.
Dopamine in the brain is a good thing for focus and drive when you are training. Boosting the brain’s dopamine before hitting the gym is a goal of lots of pre-workout powders. The great thing is that Acetyl L-Carnitineachieves this goal3, while also have the wonderful ‘side effect’ of promoting fat burning.
Dopamine is a hormone that governs much of our brain activity. Dopamine is associated with many neurological functions: cognition, learning, attention, memory, desire, pleasure, punishment, reward, motivation, sleep, mood, behaviour, and voluntary movement. It is no wonder that Acetyl L-Carnitine is a ‘must take’ supplement for the serious trainer.
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